DNA Computing and Informatics at Surfaces
Robert M. Corn -- Department of Chemistry
University of California, Irvine, CA 92697 USA
Lloyd M. Smith -- Department of Chemistry
University of Wisconsin, Madison, WI 53706 USA
Anne E. Condon -- Department of Computer Science
University of British Columbia, Vancouver, B.C., V6T 1Z4 Canada
| Overview |
This research project is aimed at the
development and characterization of complex mixtures of DNA molecules
attached to surfaces. The attachment chemistry, hybridization chemistry
and enzymatic activity of the adsorbed DNA molecules will be characterized
by a variety of spectroscopic and biochemical methods, and subsequently
optimized for use in (i) the manipulation of DNA sequences in molecular
computing strategies and (ii) the high density storage and retrieval of
information by DNA hybridization chemistry.
A List of Our DNA Computing Papers:
- Ming Li, Hye Jin Lee, Ann E. Condon and Robert M. Corn,
"A DNA Word Design Strategy for Creating Sets of Non-Interacting
Oligonucleotides for DNA Microarrays,"
Langmuir, 73 805-812 (2002).
- Emily A. Smith, Matt J. Wanat, Yufei Cheng, Sergio V. P. Barreira,
Anthony G. Frutos and Robert M. Corn,
"Formation, Spectroscopic Characterization and
Application of Sulfhydryl-Terminated Alkanethiol Monolayers for the
Chemical Attachment of DNA onto Gold Surfaces,"
Langmuir, 17 2502-2507 (2001).
- Liman Wang, Qinghua Liu, Robert M. Corn, Anne E. Condon
and Lloyd M. Smith,
"Multiple Word DNA Computing on Surfaces"
J. Am. Chem. Soc., 122 7435-7440 (2000).
- Qinghua Liu, Liman Wang, Anthony G. Frutos, Anne E. Condon,
Corn, and Lloyd M. Smith,
"DNA Computing on Surfaces,"
Nature, 403 175-179 (2000).
- "Reversible Protection and Reactive Patterning of Amine and
Hydroxyl-Terminated Self-Assembled Monolayers on Gold Surfaces for the
Fabrication of Biopolymer Arrays,"
Anthony G. Frutos, Jennifer M. Brockman and Robert M. Corn,
Langmuir, 16 2192-2197 (2000).
- "A Multi-Step Chemical Modification Procedure to Create DNA Arrays on
Gold Surfaces for the Study of Protein-DNA Interactions with Surface
Plasmon Resonance Imaging,"
Jennifer M. Brockman, Anthony G. Frutos and Robert M. Corn,
J. Am. Chem. Soc., 121 8044-8051 (1999).
"Enzymatic Ligation Reactions of DNA "Words" on Surfaces for DNA Computing,"
Anthony G. Frutos, Lloyd M. Smith, and Robert M. Corn,
J. Am. Chem. Soc., 120 10277 (1998).
"Demonstration of a Word Design Strategy for DNA Computing on Surfaces,"
Anthony G. Frutos, Qinghua Liu, Andrew J. Thiel, Anne Marie W. Sanner,
Anne E. Condon, Lloyd M. Smith, and Robert M. Corn,
Nucleic Acids Research, 25 4748 (1997).
If you would like a reprint of one of these papers (most can
now be emailed to you in pdf format), please email your
request along with your name
and mailing address to us at:
Additional preprints of our papers on DNA computing that are
available in PDF versions:
"Reducing Errors in DNA Computing by Appropriate Word Design,"
Jesse M. Gray, Tony G. Frutos, A. Michael Berman, Anne E. Condon, Max G.
Lagally, Lloyd M. Smith and Robert M. Corn,
PDF Version or
"On Combinatorial Word Design,"
Amit Maranthe, Anne E. Condon, Robert M. Corn,
DIMACS Series in Discrete Mathematics and
Theoretical Computer Science, 54 75-90 (2000).
If You Want To Learn More, Please Contact:
DNA image obtained from: www.imb-jena.de